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Nonvascular retinal imaging markers of preclinical Alzheimer’s disease.

Authors: Alber J, Fernández B, Johnson LN, Lim YY, Maruff P, Santos CY, Snyder PJ

Journal: Alzheimer's & Dementia

Volume & Issue: 4

Page No.: 169-178

Year Published: 2016

INTRODUCTION: In patients with Alzheimer’s disease (AD) and mild cognitive impairment, structural changes in the retina (i.e., reduced thicknesses of the ganglion cell and retinal nerve fiber layers and inclusion bodies that appear to contain beta-amyloid protein [Ab]) have been previously reported. We sought to explore whether anatomic retinal changes are detectable in the preclinical […]

Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer’s disease.

Authors: Ames D, Bourgeat P, Buckley RF, Ellis KA, Lautenschlager N, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Savage G, Villemagne VL

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2015.12.013

Year Published: 2016

INTRODUCTION: The objective of this study was to determine the utility of subjective memory decline (SMD) to predict episodic memory change and rates of clinical progression in cognitively normal older adults with evidence of high β-amyloid burden (CN Aβ+). METHODS: Fifty-eight CN Aβ+ participants from the Australian Imaging, Biomarkers, and Lifestyle study responded to an […]

Relationships between performance on the Cogstate Brief Battery, neurodegeneration, and Aβ accumulation in cognitively normal older adults and adults with MCI

Authors: Ames D, Bourgeat P, Ellis KA, Harrington K, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rembach A, Rowe CC, Salvado O, Snyder PJ, Villemagne VL

Journal: Archives of Clinical Neuropsychology

Volume & Issue: 30 & 1

Page No.: 49-58

DOI: 10.1093/arclin/acu068

Year Published: 2015

We investigated the extent to which decline in memory and working memory in beta-amyloid (Aβ) positive non-demented individuals was related to hippocampal atrophy and Aβ accumulation over 36 months. Cognitively normal older adults (CN) (n = 178) and adults with mild cognitive impairment (MCI) (n = 49) underwent positron emission tomography neuroimaging, magnetic resonance imaging, […]

Aβ and cognitive change: Examining the preclinical and prodromal stages of Alzheimer’s disease

Authors: Ames D, Darby D, Ellis KA, Harrington K, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rowe CC, Savage G, Szoeke C, Villemagne VL

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2013.11.005

Year Published: 2014

BACKGROUND: High β-amyloid (Aβ) is associated with faster memory decline in healthy individuals and adults with mild cognitive impairment (MCI). However, longer prospective studies are required to determine if Aβ-related memory decline continues and whether it is associated with increased rate of disease progression. METHODS: Healthy controls (HCs; n = 177) and adults with MCI […]