Publications

Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.

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Reliability and validity of the CogState computerized battery in patients with seizure disorders and healthy young adults: comparison with standard neuropsychological tests.

Authors: Bowden SC, Cook MJ, Fratti S

Journal: The Clinical Neuropsychologist

Page No.: 1-18

Year Published: 2016

OBJECTIVE: The aim was to examine the reliability and validity of two measures of learning and memory within the CogState Computerized Battery: the One Card Learning (OCL) and the Continuous Paired Associative Learning (CPAL). Comparison of various reliable change measures was also included to examine rate of correct cognitive change classification, in particular, when using […]

The impact of administration order in studies of computerized neurocognitive assessment tools (NCATs).

Authors: Arrieux JP, Cole WR, Dennison EM, Ivins BJ

Journal: Journal of Clinical and Experimental Neuropsychology

Year Published: 2016

Computerized neurocognitive assessment tools (NCATs) have become a common way to assess postconcussion symptoms. As there is increasing research directly comparing multiple NCATs to each other, it is important to consider the impact that order of test administration may have on the integrity of the results. This study investigates the impact of administration order in […]

Sensitivity of composite scores to amyloid burden in preclinical Alzheimer’s disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score.

Authors: Ames D, Bourgeat P, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rowe CC, Salvado O, Snyder PJ, Ukiqi A, Villemagne VL

Journals: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Volume & Issue: 2

Page No.: 19-26

DOI: 10.1016/j.dadm.2015.11.003

Year Published: 2016

INTRODUCTION: Cognitive composite scores developed for preclinical Alzheimer’s disease (AD) often consist of multiple cognitive domains as they may provide greater sensitivity to detect β-amyloid (Aβ)-related cognitive decline than episodic memory (EM) composite scores alone. However, this has never been empirically tested. We compared the rate of cognitive decline associated with high Aβ (Aβ+) and […]

Validation of the CogState battery for rapid neurocognitive assessment in Ugandan school age children.

Authors: Bangirana P, Boivin MJ, Giordani B, Nakasujja N, Sikorskii A

Journal: Child and Adolescent Psychiatry and Mental Health

DOI: 10.1186/s13034-015-0063-6

Year Published: 2015

BACKGROUND: CogState is a widely used computer-based cognitive test whose validity has not been addressed in resource poor settings. We examined the construct, concurrent and convergent validity of CogState, test-retest reliability and the effect of sociodemographic variables on CogState outcomes in school age children. METHODS: Two hundred and thirty Ugandan children (54% male) with mean […]

Relationships between performance on the Cogstate Brief Battery, neurodegeneration, and Aβ accumulation in cognitively normal older adults and adults with MCI

Authors: Ames D, Bourgeat P, Ellis KA, Harrington K, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rembach A, Rowe CC, Salvado O, Snyder PJ, Villemagne VL

Journal: Archives of Clinical Neuropsychology

Volume & Issue: 30 & 1

Page No.: 49-58

DOI: 10.1093/arclin/acu068

Year Published: 2015

We investigated the extent to which decline in memory and working memory in beta-amyloid (Aβ) positive non-demented individuals was related to hippocampal atrophy and Aβ accumulation over 36 months. Cognitively normal older adults (CN) (n = 178) and adults with mild cognitive impairment (MCI) (n = 49) underwent positron emission tomography neuroimaging, magnetic resonance imaging, […]

Mild cognitive impairment can be detected by multiple assessments in a single day.

Authors: Collie A, Darby D, Maruff P, McStephen M

Journal: Neurology

Volume & Issue: 59 & 7

Page No.: 1042-6

Year Published: 2002

BACKGROUND: Reliable detection of mild cognitive impairment (MCI), in many cases preceding AD, is important in determining the efficacy of emerging treatments. The operational definition of MCI is currently imprecise and would be improved by objective criteria. Inherent in the transition from MCI to AD is cognitive decline, which can be detected using multiple assessments […]

Behavioral characterization of mild cognitive impairment.

Authors: Collie A, Currie J, Maruff P

Journal: Journal of Clinical and Experimental Neuropsychology

Volume & Issue: 24 & 6

Page No.: 720-33

Year Published: 2002

Results from recent investigations of behavioral and genetic outcomes in older people with mild cognitive impairment (MCI) have been inconsistent. These conflicting results may be attributed to between-study differences in the diagnostic systems employed, as well as the use of unreliable neuropsychological measures. We investigated behavioral and genetic outcomes in older people classified as having […]

Increased anti-saccade latency is an isolated lingering abnormality in Sydenham chorea.

Authors: Cairney S, Currie BJ, Currie J, Maruff P

Journal: Journal of Neuro-ophthalmology

Volume & Issue: 29 & 2

Page No.: 143-5

DOI: 10.1097/WNO.0b013e3181a58dfa

Year Published: 2009

Sydenham chorea (SC) is an autoimmune response to group A beta-hemolytic streptococcal infection whose clinical and imaging manifestations usually resolve within 6 months. We used ocular motor analysis and neuropsychologic assessment to investigate residual striatal dysfunction in two individuals with histories of childhood SC whose most recent episodes of chorea had occurred 5 and 17 […]

Assessing cognitive function in cancer patients.

Authors: Maruff P, Park A, Tannock IF, Vardy J, Wagner L, Wong K, Yi QL

Journal: Supportive Care in Cancer

Volume & Issue: 14 & 11

Page No.: 1111-8

DOI: 10.1007/s00520-006-0037-6

Year Published: 2006

GOALS OF WORK: Some patients with cancer suffer cognitive impairment after chemotherapy. A brief, sensitive instrument is required to screen patients for cognitive impairment. In this study, we compare three possible screening instruments. MATERIALS AND METHODS: Cancer patients (n=31) who had received adjuvant chemotherapy within 2 years underwent cognitive evaluation on three occasions. Fluent English […]

The influence of different error estimates in the detection of post-operative cognitive dysfunction using reliable change indices with correction for practice effects.

Authors: Evered LA, Lewis MS, Maruff P, Scott DA, Silbert BS

Journal: Archives of Clinical Neuropsychology

Volume & Issue: 21 & 5

Page No.: 421-7

Year Published: 2006

The reliable change index (RCI) expresses change relative to its associated error, and is useful in the identification of post-operative cognitive dysfunction (POCD). This paper examines four common RCIs that each account for error in different ways. Three rules incorporate a constant correction for practice effects and are contrasted with the standard RCI that had […]

The influence of different error estimates in the detection of postoperative cognitive dysfunction using reliable change indices with correction for practice effects.

Authors: Evered LA, Lewis MS, Maruff P, Scott DA, Silbert BS

Journal: Archives of Clinical Neuropsychology

Volume & Issue: 22 & 2

Page No.: 249-57

Year Published: 2007

The reliable change index (RCI) expresses change relative to its associated error, and is useful in the identification of postoperative cognitive dysfunction (POCD). This paper examines four common RCIs that each account for error in different ways. Three rules incorporate a constant correction for practice effects and are contrasted with the standard RCI that had […]

Assessment of cognition in mild cognitive impairment: a comparative study.

Authors: Albert MS, Jackson CE, Kaye J, Khachaturian AS, Petersen RC, Snyder PJ, Weintraub S

Journal: Alzheimer's & Dementia

Volume & Issue: 7 & 3

Page No.: 338-55

DOI: 10.1016/j.jalz.2011.03.009

Year Published: 2011

The demand for rapidly administered, sensitive, and reliable cognitive assessments that are specifically designed for identifying individuals in the earliest stages of cognitive decline (and to measure subtle change over time) has escalated as the emphasis in Alzheimer’s disease clinical research has shifted from clinical diagnosis and treatment toward the goal of developing presymptomatic neuroprotective […]

Rapid decline in episodic memory in healthy older adults with high amyloid-β.

Authors: Ames D, Ashwood T, Bush AI, Darby D, Ellis KA, Harrington K, Jaeger J, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rowe CC, Szoeke C, Villemagne VL

Journal: Journal of Alzheimer's Disease

Volume & Issue: 33 & 3

Page No.: 675-9

DOI: 10.3233/JAD-2012-121516

Year Published: 2013

High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate […]