Neurocognitive effects of repeated ketamine infusions in comorbid posttraumatic stress disorder and major depressive disorder
Background: The glutamate N-methyl-d-aspartate (NMDA) receptor antagonist ketamine rapidly ameliorates posttraumatic stress disorder (PTSD) and depression symptoms in individuals with comorbid PTSD and major depressive disorder (MDD). However, concerns over ketamine’s potential neurocognitive side effects have […]
A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy
Background: The purpose of this study was to evaluate the effects of adding ketamine to propofol on cognitive functions in patients undergoing sedation for colonoscopy. Methods: In this randomized, double-blinded, and controlled study, 200 patients were […]
Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242
There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation of […]
Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression
The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine’s neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive […]
