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Determining optimal impairment rating methodology for a new HIV-associated neurocognitive disorder screening procedure.

Authors: Bloch M, Brew BJ, Carberry A, Cysique LA, Kamminga J, Vincent T

Journal: Journal of Clinical and Experimental Neuropsychology

Page No.: 1-15

DOI: 10.1080/13803395.2016.1263282

Year Published: 2017

INTRODUCTION: The current study sought to determine the optimal impairment rating definition for a new HIV-associated neurocognitive disorder (HAND) screening procedure as compared to standard neuropsychological testing. METHOD: A total of 55 HIV-infected (HIV+; 19% AIDS; 87% on combination antiretroviral therapy, cART; 80% plasma undetectable) and 22 demographically comparable HIV-uninfected (HIV-) control adults (all male) […]

Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV.

Authors: Anderson J, Boffito M, De Francesco D, Mallon PW, Post FA, Sabin C, Sachikonye M, Underwood J, Vera JH, Williams I, Winston A

Journal: HIV Medicine

DOI: 10.1111/hiv.12434

Year Published: 2016

OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState™ ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 […]

A Randomized Controlled Trial to Evaluate if Computerized Cognitive Rehabilitation Improves Neurocognition in Ugandan Children with HIV.

Authors: Boivin MJ, Giordani B, Nakasujja N, Opoka RO, Sikorskii A

Journal: AIDS Research and Human Retroviruses

Volume & Issue: 32 & 18

Page No.: 743-55

DOI: 10.1089/AID.2016.0026

Year Published: 2016

OBJECTIVES: Clinically stable children with HIV can have neuromotor, attention, memory, visual-spatial, and executive function impairments. We evaluated neuropsychological and behavioral benefits of computerized cognitive rehabilitation training (CCRT) in Ugandan HIV children. DESIGN: One hundred fifty-nine rural Ugandan children with WHO Stage I or II HIV disease (6 to 12 years; 77 boys, 82 girls; […]

A Screening Strategy for HIV-Associated Neurocognitive Disorders That Accurately Identifies Patients Requiring Neurological Review.

Authors: Bailey M, Bloch M, Brew B, Carberry A, Cysique LA, Jayewardene A, Kamminga J, Maruff P, Quan D, Vincent T

Journal: Clinical Infectious Diseases

Volume & Issue: 63 & 5

Page No.: 687-93

DOI: 10.1093/cid/ciw399

Year Published: 2016

BACKGROUND: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are not routinely assessed due to the lack of an adequate screening strategy. We aimed to develop a clinically relevant screening procedure for symptomatic HAND, validated against a gold standard neuropsychological (NP) test battery. METHODS: Representative HIV-infected (HIV+) and demographically matched HIV-uninfected (HIV-) participants in an observational […]

A cross-sectional study to evaluate the association of hyperbilirubinaemia on markers of cardiovascular disease, neurocognitive function, bone mineral density and renal markers in HIV-1 infected subjects on protease inhibitors.

Authors: Asboe D, Barber TJ, Boffito M, Hill A, Jagjit Singh G, Moyle G, Nelson M, Scourfield A, Waters L, Yapa HM

Journal: HIV Clinical Trials

Volume & Issue: 17 & 3

Page No.: 123-30

DOI: 10.1080/15284336.2016.1176305

Year Published: 2016

BACKGROUND: Ongoing inflammation in controlled HIV infection contributes to non-AIDS comorbidities. High bilirubin appears to exhibit an anti-inflammatory effect in vivo. We therefore examined whether increased bilirubin in persons with HIV was associated with differences in markers of inflammation and cardiovascular, bone, renal disease, and neurocognitive (NC) impairment. METHODS: This cross-sectional study examined inflammatory markers […]

A Randomized Controlled Trial to Evaluate if Computerized Cognitive Rehabilitation Improves Neurocognition in Ugandan Children with HIV.

Authors: Boivin MJ, Giordani B, Nakasujja N, Opoka RO, Sikorskii A

Journal: AIDS Research and Human Retroviruses

Volume & Issue: 32 & 8

Page No.: 743-55

DOI: 10.1089/AID.2016.0026

Year Published: 2016

OBJECTIVES: Clinically stable children with HIV can have neuromotor, attention, memory, visual-spatial, and executive function impairments. We evaluated neuropsychological and behavioral benefits of computerized cognitive rehabilitation training (CCRT) in Ugandan HIV children. DESIGN: One hundred fifty-nine rural Ugandan children with WHO Stage I or II HIV disease (6 to 12 years; 77 boys, 82 girls; […]

Cerebral function in perinatally HIV-infected young adults and their HIV-uninfected sibling controls.

Authors: Allsop J, Ashby J, Fidler S, Foster C, Garvey L, Paramesparan Y, Taylor-Robinson SD, Wan T, Winston A

Journal: HIV Clinical Trials

Volume & Issue: 16 & 2

Page No.: 81-7

DOI: 10.1179/1528433614Z.0000000003

Year Published: 2015

BACKGROUND: Perinatally acquired HIV-infected (PaHIV) young adults undergo neurodevelopment in the presence of HIV infection and antiretroviral therapy, which may lead to neurocognitive (NC) impairment. Knowledge of NC function in this group is sparse and control data lacking. We compared cerebral function in young adults with PaHIV infection to aged matched HIV negative family controls. […]

Antiretroviral therapy in HIV infection: are neurologically active drugs important?

Authors: Brew BJ, Cysique LA, Maruff P

Journal: Archives of Neurology

Volume & Issue: 61 & 11

Page No.: 1699-704

DOI: 10.1001/archneur.61.11.1699

Year Published: 2004

BACKGROUND: The effect on neuropsychological function of antiretroviral drugs that are able to penetrate into the brain in effective concentration (neuroactive drugs) remains unclear. OBJECTIVE: To investigate whether highly active antiretroviral therapy (HAART) containing neuroactive drugs is associated with better neuropsychological performance in patients with human immunodeficiency virus disease. DESIGN: Cross-sectional survey. SETTING: Tertiary referral […]

Variable benefit in neuropsychological function in HIV-infected HAART-treated patients.

Authors: Brew BJ, Cysique LA, Maruff P

Journal: Neurology

Volume & Issue: 66 & 9

Page No.: 1447-50

Year Published: 2006

The authors examined cognitive performance change in 101 individuals with advanced HIV infection on highly active antiretroviral therapy (HAART), using standard neuropsychological testing in three visits, over a 27-month-period. Cognitive performance stabilized in a majority of HIV+ participants over time. A neuroactive HAART regimen was associated with neuropsychological improvement. Decline occurred in a minority with […]

The neuropsychological profile of symptomatic AIDS and ADC patients in the pre-HAART era: a meta-analysis.

Authors: Brew BJ, Cysique LA, Maruff P

Journal: Journal of the International Neuropsychological Society

Volume & Issue: 12 & 3

Page No.: 368-82

Year Published: 2006

It remains essential to document the neuropsychological profile of acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) and minor forms human immunodeficiency virus (HIV)-associated neurocognitive impairment by quantifying the magnitude of impairment across eras of treatment. Indeed, with the introduction of the highly active antiretroviral therapy (HAART), there is evidence of changes in aspects of ADC. […]

Valproic acid is associated with cognitive decline in HIV-infected individuals: A clinical observational study.

Authors: Brew BJ, Cysique LA, Maruff P

Journal: BMC Neurology

Volume & Issue: 6

Page No.: 42

Year Published: 2006

BACKGROUND: Valproic acid (VPA) is often used to control pain in HIV-related neuropathy. However, the effect of VPA on cognitive functions in advanced HIV-infected individuals is largely unknown. A recent study would suggest that it may have a neuroprotective effect, the doses used were low and the observation period short. METHODS: We used a well […]

A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV.

Authors: Bangirana P, Boivin MJ, Busman RA, Giordani B, Opoka RO, Page CF, Parikh SM

Journal: Neuropsychology

Volume & Issue: 24 & 5

Page No.: 667-73

DOI: 10.1037/a0019312

Year Published: 2010

OBJECTIVE: Because antiretroviral treatment (ART) fails to improve neurocognitive impairment in children with HIV, we completed a pilot study evaluating the feasibility and cognitive benefit of computerized cognitive rehabilitation therapy (CCRT) in Ugandan children with HIV. METHOD: Sixty Ugandan children with HIV (23 on ART) were randomly assigned to 10 sessions of Captain’s Log CCRT […]

HIV and age do not substantially interact in HIV-associated neurocognitive impairment.

Authors: Bain MP, Brew BJ, Cysique LA, Maruff P, Wright E

Journal: The Journal of Neuropsychiatry and Clinical Neurosciences

Volume & Issue: 23 & 1

Page No.: 83-9

DOI: 10.1176/appi.neuropsych.23.1.83

Year Published: 2011

The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status × […]

Effect of hyperbilirubinaemia on neurocognitive, renal, bone and cardiovascular markers in HIV infection treated with boosted protease inhibitors.

Authors: Barber TJ, Boffito M, Hill A, Moyle G, Nelson M, Singh GJ

Journal: Journal of the International AIDS Society

Volume & Issue: 17 (4 Suppl 3)

DOI: 10.7448/IAS.17.4.19827

Year Published: 2014

INTRODUCTION: Use of some protease inhibitors (PI) is associated with unconjugated hyperbilirubinaemia (HBR), due to inhibition of UGT1A1. As observed in Gilbert’s syndrome, HBR may have antioxidant and anti-inflammatory effects. Inflammation may be relevant to neurocognitive (NC) impairment, cardiovascular, renal and bone co-morbidities in HIV infection. This study aimed to analyse correlations between antiretroviral associated […]

Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals?

Authors: Allsop JM, Cox JI, Garvey L, Grover VP, Main J, Scotney E, Taylor-Robinson SD, Thomson EC, Winston A, Wylezinska M, Yerrakalva D

Journal: Journal of Viral Hepatitis

Volume & Issue: 17 & 6

Page No.: 419-26

DOI: 10.1111/j.1365-2893.2009.01198.x

Year Published: 2010

Central nervous system (CNS) manifestations of chronic hepatitis C virus (HCV) and chronic human immune deficiency virus-1 (HIV-1) infections have been reported, but the impact of acute HCV infection on the CNS is unknown. A total of 10 individuals with chronic stable HIV-1 with documented acute HCV (HCV-RNA polymerase chain reaction positive and HCV antibody […]

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