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Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.

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Convergent and criterion validity of the CogState computerized brief battery cognitive assessment in women with and without breast cancer.

Authors: Delgado N, Fernandez N, Lo TTY, Meier AM, Moore C, Patel SK

Journal: The Clinical Neuropsychologist

Page No.: 1-2

DOI: 10.1080/13854046.2016.1275819

Year Published: 2017

OBJECTIVE: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional ‘pencil and-paper’ neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized […]

Reliability and validity of the CogState computerized battery in patients with seizure disorders and healthy young adults: comparison with standard neuropsychological tests.

Authors: Bowden SC, Cook MJ, Fratti S

Journal: The Clinical Neuropsychologist

Page No.: 1-18

Year Published: 2016

OBJECTIVE: The aim was to examine the reliability and validity of two measures of learning and memory within the CogState Computerized Battery: the One Card Learning (OCL) and the Continuous Paired Associative Learning (CPAL). Comparison of various reliable change measures was also included to examine rate of correct cognitive change classification, in particular, when using […]

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease.

Authors: Asthana S, Berman SE, Bilgel M, Blennow K, Carlsson CM, Christian BT, Clark LR, Jedynak B, Johnson SC, Koscik RL, Mueller KD, Nicholas CR, Norton D, Racine AM, Zetterberg H

Journal: Journal of Alzheimer's Disease

DOI: 10.3233/JAD-160528

Year Published: 2016

It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer’s disease(AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer’s Prevention(mean age 63.8±7 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated […]

Cognitive, physical and physiological responses of school boy cricketers to a 30-over batting simulation.

Authors: Christie CJ, Goble D

Journal: Journal of Sports Sciences

Page No.: 1-7

Year Published: 2016

The purpose of this study was to assess how cognitive and physical performance are affected during a prolonged, fatigue-inducing cricket-batting simulation. Fifteen amateur batters from three Eastern Cape schools in South Africa were recruited (mean ± SD: age 17 ± 0.92 years; stature 1.75 ± 0.07 m; body mass 78.3 ± 13.2 kg). Participants completed […]

The Relationship between Nutrition in Infancy and Cognitive Performance during Adolescence.

Authors: Foster JK, Hickling S, Li J, Nyaradi A, Oddy WH

Journal: Frontiers in Nutrition

DOI: 10.3389/fnut.2015.00002

Year Published: 2015

OBJECTIVES: In this study, we aimed to investigate the long-term associations between breastfeeding duration during infancy, diet quality as measured by a diet score at 1 year of age, and cognitive performance during adolescence. METHODS: Participants (n = 717) were recruited from the West Australian Pregnancy Cohort (Raine) Study, a prospective longitudinal study of 2868 children and their […]

The effect of histidine on mental fatigue and cognitive performance in subjects with high fatigue and sleep disruption scores.

Authors: Fujimura N, Furuhata Y, Nozawa Y, Sasahara I, Sato H

Journal: Physiology & Behavior

DOI: 10.1016/j.physbeh.2015.04.042

Year Published: 2015

Our previous study reported that a dried bonito broth known in Japan as ‘dashi’ improved or ameliorated mood states, including fatigue, during the daily lives of human subjects. Histidine is an amino acid that is present in dried bonito broth, and we sought to evaluate whether histidine would affect feelings of fatigue in humans. We […]

An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia.

Authors: Hasegawa T, Hashimoto K, Hashimoto T, Iyo M, Kanahara N, Oda Y, Sasaki T, Shiina A, Yoshida T

Journal: Clinical Psychopharmacology and Neuroscience

Volume & Issue: 13 & 1

Page No.: 62-7

DOI: 10.9758/cpn.2015.13.1.62

Year Published: 2015

OBJECTIVE: Schizophrenia is a mental disorder characterized by severe cognitive impairment. Accumulating evidence suggests a role for oxidative stress in the pathophysiology of schizophrenia. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. In this study, we attempted to evaluate the effect of SFN on cognitive impairment in medicated […]

Developmental Trajectory of Information-Processing Skills in Children: Computer-Based Assessment

Authors: Anderson V, Clausen H, Collie A, Crowe LM, Davis G, Dooley J, Maddocks D, Mccrory P, Williams J

Journal: Applied neuropsychology. Child

Page No.: 1-9

Year Published: 2014

There are significant merits to a comprehensive cognitive assessment, but they are also time-consuming, costly, and susceptible to practice effects and may not detect change in the context of medical interventions or minor brain disruptions. Brief computer-based assessments focused on “fluid” cognitive domains (e.g., information-processing skills), which are vulnerable to disruption as a result of […]

Practice effects associated with the repeated assessment of cognitive function using the CogState battery at 10-minute, one week and one month test-retest intervals.

Authors: Collie A, Darby DG, Falleti MG, Maruff P

Journal: Journal of Clinical and Experimental Neuropsychology

Volume & Issue: 28 & 7

Page No.: 1095-112

Year Published: 2006

There are many situations in which cognitive tests need to be administered on more than two occasions and at very brief test-retest intervals to detect change in group performance. However, previous literature has not specifically addressed these important issues. The main aim of the current study was to examine these two factors by using a […]

Validity of a brief computerized cognitive screening test in dementia.

Authors: Barbas N, Darby D, Giordani B, Hammers D, Heidebrink J, Persad C, Ryan K, Spurgeon E

Journal: Journal of Geriatric Psychiatry and Neurology

Volume & Issue: 25 & 2

Page No.: 89-99

DOI: 10.1177/0891988712447894

Year Published: 2012

BACKGROUND: While preliminary evidence supports the criterion validity of the CogState computerized brief battery in mild cognitive impairment (MCI) and Alzheimer disease (AD), definitive validation studies examining a wider range of dementia-related disorders relative to conventional neuropsychological techniques are necessary. METHODS: Participants satisfying clinical consensus criteria for dementia (AD, n = 37; frontotemporal dementia, n […]

The effects of practice on the cognitive test performance of neurologically normal individuals assessed at brief test-retest intervals.

Authors: Collie A, Darby DG, Maruff P, McStephen M

Journal: Journal of the International Neuropsychological Society

Volume & Issue: 9 & 3

Page No.: 419-28

Year Published: 2003

Performance on many cognitive and neuropsychological tests may be improved by prior exposure to testing stimuli and procedures. These beneficial practice effects can have a significant impact on test performance when conventional neuropsychological tests are administered at test-retest intervals of weeks, months or years. Many recent investigations have sought to determine changes in cognitive function […]

Qualitative similarities in cognitive impairment associated with 24 h of sustained wakefulness and a blood alcohol concentration of 0.05%.

Authors: Collie A, Darby DG, Falleti MG, Maruff P, McStephen M

Journal: Journal of Sleep Research

Volume & Issue: 12 & 4

Page No.: 265-74

DOI: 10.1111/j.1365-2869.2003.00363.x

Year Published: 2003

Previous studies that have quantified fatigue-related cognitive impairment as blood alcohol concentration (BAC) equivalents have been limited by two issues: the effect of practice on tests of cognition and, more importantly, the statistic used to quantify change in cognitive performance. The current study addressed these issues by adopting an ABACA design, which allowed for the […]

Cognitive testing in early phase clinical trials: Outcome according to adverse event profile in a Phase I study.

Authors: Collie A, Darekar MA, Huggins JP, Maruff P, Snyder PJ

Journal: Human Psychopharmacology

Volume & Issue: 21 & 7

Page No.: 481-8

Year Published: 2006

BACKGROUND: It has been proposed that objective cognitive testing provides additional information to that collected via adverse event (AE) recordings. However, in clinical trials of compounds with potentially negative effects on cognition, the results of cognitive testing may overlap with AE recordings. AIMS: To examine cognitive function in subjects who do and do not report […]

Cognitive testing in early-phase clinical trials: development of a rapid computerized test battery and application in a simulated Phase I study.

Authors: Collie A, Darekar A, Huggins JP, Maruff P, Snyder PJ, Toh MK, Weissgerber G

Journal: Contemporary Clinical Trials

Volume & Issue: 28 & 4

Page No.: 391-400

Year Published: 2007

BACKGROUND: Inclusion of cognitive assessment in Phase I trials of novel pharmaceutical agents may help identify subtle yet meaningful CNS effects early in clinical development, and lead to a greater understanding of the pharmacokinetic/pharmacodynamic relationship prior to entering pivotal late-phase trials. AIMS: To examine issues surrounding the inclusion of a computerised cognitive test battery in […]

Detection of MCI in the clinic: Evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE.

Authors: Budge MM, de Jager CA, Honey TE, Schrijnemaekers AC

Journal: Age Ageing

Volume & Issue: 38 & 4

Page No.: 455-60

DOI: 10.1093/ageing/afp068

Year Published: 2009

INTRODUCTION: The sensitive detection of mild cognitive impairment (MCI) in older adults is an important problem that requires objective assessment. We evaluated whether the computerised cognitive test battery, CogState, was as sensitive to MCI as two well-validated ‘paper-and-pencil’ tests, the Hopkins Verbal Learning Test (HVLT) and the Mini-Mental Status Examination (MMSE). METHODS: These tests were […]

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