Feasibility of Utilizing a Brief Neurocognitive Battery in 3-Year-Old Patients During Treatment for Acute Lymphoblastic Leukemia

January 13, 2025

Authors: Sameera Ramjan, Peter D Cole, Melanie Blair-Thies, Lewis B Silverman, Amy Fredrickson, Adrian Schembri, Jennifer J Greene Welch, Justine Kahn, Kara M Kelly, Thai-Hoa Tran, Bruno Michon, Lisa Gennarini, Stephen A Sands

Journal: Pediatric Blood & Cancer

DOI: 10.1002/pbc.31469

Year Published: 2024

Treatment of acute lymphoblastic leukemia (ALL) is associated with neurocognitive deficits in young children. While computerized measures have been utilized in pediatric oncology research, they exclude patients below the age of 4 years. Patients enrolled on “Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents” were offered participation in an optional neurocognitive study. Three-year old patients did not differ from 4-year-old patients in their ability to perform or complete the tests. Including patients diagnosed at age 3 will serve to improve our understanding of at-risk patients and their neurocognitive trajectory both during and after treatment.

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