Posters
Read research from Cogstate scientists as presented at industry conferences.
Data Quality Monitoring of Bayley Assessments: Error Detection in Rare Neurodevelopmental Disorder Trials
ISCTM 2026
Neurodevelopmental outcome measures such as the Bayley-III require high inter-rater reliability and strict adherence to standardized administration procedures. In trials of rare disorders, decentralized data collection across sites with variable assessor experience introduces risk for administration and scoring errors. While centralized data quality monitoring approaches are increasingly adopted, relatively few studies describe how identified errors are evaluated, corrected, and quality-controlled at the reviewer level. This analysis examines error frequency, magnitude of score change, and type of error that led to a score change across Bayley-III administrations.
View PosterComparative Performance of Video and Record Form Review Methods for Bayley Administration Fidelity
ISCTM 2026
Ensuring the fidelity of Bayley administrations is essential to data integrity in rare NDD clinical trials. Administration errors such as inaccurate start or stop points, incorrect item delivery, and scoring inaccuracies can threaten endpoint validity. While record-form review offers insight into scoring and documentation accuracy, it cannot evaluate examiner behavior. In contrast, video review allows full observation of administration procedures in addition to review of the record form but requires greater resources. Understanding the relative sensitivity of these approaches is essential for optimizing central-review strategies and ensuring high-quality data.
View PosterEquivalency of Self-Administered App (LILA) and Telehealth Administration of the International Shopping List Test
ADPD 2026
Self-administered digital cognitive assessments offer the opportunity for cost efficient and scalable screening for cognitive impairment associated with Alzheimer’s Disease. Episodic memory decline is a cognitive hallmark of AD, and provides a key domain for detecting and monitoring early cognitive changes associated with the disease. The International Shopping List Test (ISLT) is a validated test of episodic memory, shown to differentiate between clinical disease stages, and to be sensitive to amyloid-β associated cognitive decline in MCI and cognitively unimpaired individuals. LILA is an app that adapts the ISLT for self-administration via smartphone, that has been shown to be feasible and have good acceptability for older adults.
View PosterFeasibility and accuracy of the LILA app: Pilot study of a fully remote, self-administered, verbal list learning task for community cognitive screening
CTAD 2025
Cost efficient and scalable screening strategies are critically needed to identify individuals who could most benefit from pharmaceutical therapies for Alzheimer’s Disease (AD). Digital cognitive assessments that are sensitive to changes in learning and episodic memory offer the opportunity for community screening of cognitive function to identify individuals in the early stages of AD. LILA is a self-administered assessment completed via smartphone app, which leverages the well validated International Shopping List Test (ISLT) to assess learning and episodic memory.
View PosterCharacterizing patient-reported cognitive difficulties and their impact on daily life in narcolepsy type 1
SLEEP 2025
Narcolepsy Type 1 (NT1) is a rare neurological disorder caused by the loss of orexin-producing neurons, leading to disrupted sleep and other symptoms like cataplexy and hallucinations. Beyond sleep issues, NT1 significantly affects various biological functions, including cognition. Cognitive difficulties—both measured and self-reported—are increasingly seen as central to the disorder’s impact, though patient-reported challenges remain under-researched.
View PosterUse of the Psychomotor Vigilance Test in clinical trials of CNS-active drugs: a systematic review and meta-analysis
SLEEP 2025
People with central hypersomnolence disorders often struggle with cognition—especially sustained attention. The Psychomotor Vigilance Test (PVT) is commonly used to assess these issues, but study designs and outcome measures vary. Better use of PVT in clinical trials requires insights from past studies and reference data on normal and abnormal performance, as well as responsiveness to sleep-related changes or sedatives.
View PosterRemote assessment of cognition with the unsupervised version of the Cogstate Brief Battery: Association of composite endpoints with Alzheimer’s disease biomarkers
ISCTM 2025
With recent approval of disease modifying therapies for early symptomatic Alzheimer’s disease (AD), interest has grown in secondary prevention trials (defined as the presence of AD pathology in clinically normal individuals). However, it takes screening massive numbers of people to identify cognitively normal people with biomarker evidence of AD. Cognitive assessment can be made efficient through use of internet based registries, which can be linked to clinical trials for potential therapies, but understanding of the relationship between performance on assessments and AD biomarkers is needed. The Cogstate Brief Battery (CBB), a compilation of 4 cognitive tests, has been optimized for unsupervised, remote use in registries. To determine the utility of validity of data collected from remote administration of the CBB, data from cognitively unimpaired (CU) middle aged adults with various AD risk factors, enrolled in a registry, were investigated for relationships with in-clinic performance on standardized neuropsychological assessments and with AD biomarkers obtained from cerebral spinal fluid (CSF) sampling.
View PosterAcceptability and Validity of the Smartphone-Administered Version of the Cogstate Brief Battery in Adult Participants of the Healthy Brain Project
ISCTM 2025
This poster presents findings from a study examining the acceptability and validity of the smartphone-administered version of the Cogstate Brief Battery (CBB) in cognitively unimpaired middle-aged and older adults. Unsupervised, remote administration of cognitive tests may lead to more accessible and accurate representations of cognitive function in everyday life compared to in-clinic neuropsychological assessments.
View PosterAcceptability and validity of a smartphone-administered word list learning test (LILA) in cognitively unimpaired adults
The Healthy Brain Project
This poster presents findings from a study examining the acceptability of a remote self-administered version of the International Shopping List Test (ISLT™), known as LILA, in cognitively unimpaired middle-aged and older adults. The ISLT™ is a rater-administered verbal list learning test used to detect memory dysfunction in early Alzheimer’s disease (AD). The validity of LILA was assessed by analyzing learning curves and exploring relationships between key demographic factors, such as age, sex, education, and mood, that are known to influence cognitive performance.
View PosterCentral Monitoring and Data Quality Assurance: Identifying and Correcting Errors in Category and Letter Fluency Tests in CNS Clinical Trials
ISCTM 2024
This poster highlights the presence of scoring errors in both CFT and LFT administrations, emphasizing a crucial area for quality improvement. A significant portion of these reviews are impacted by errors, potentially affecting the validity and reliability of the tests. Contributing factors include the complexity of the tests, inconsistent administration practices, and human error. Addressing these issues is essential for improving the accuracy and consistency of fluency assessments, ultimately leading to more reliable outcomes in both clinical and research environments.
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