Cogstate Brief Battery

A rapid and reliable cognitive screening assessment across indications and phases of development.

The Cogstate Brief Battery™ has been used extensively as a rapid and reliable screening assessment in a range of clinical indications, including Alzheimer’s Disease, depression, schizophrenia, AIDS, dementia complex and as a measure of cognitive decline following a mild traumatic brain injury or suspected concussive episode. The Cogstate Brief Battery has also been used widely in the context of measuring cognitive dysfunction relative to healthy groups in both pediatric and adult populations.

The Cogstate Brief Battery provides a measure of four core cognitive domains: processing speed, attention, visual learning and working memory. Study teams wishing to measure all or a subset of these domains can choose the tests that best suit their specific research questions. Each of the tests have been utilized previously in clinical trials and maintain excellent reliability across repeated testing and cross-sectional research designs. This battery maintains excellent psychometric properties in relation to test-retest reliability. The criterion and construct validity of each test for cognitive impairment as well as the sensitivity of these tests to change in cognition has been demonstrated in the scientific literature, and each test has also been shown to be valid for use in different cultures and language groups.

Cogstate Tests

Detection Test

The Detection Test uses a simple reaction time paradigm to measure processing speed.

Cognitive Domain Measured: Psychomotor Function

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Identification Test

The Identification Test uses a choice reaction time paradigm to measure attention.

Cognitive Domain Measured: Attention

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One Card Learning Test

The One Card Learning Test uses a pattern separation paradigm to measure visual memory.

Cognitive Domain Measured: Visual Learning

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One Back Test

The One Back Test uses an n-back paradigm to measure working memory.

Cognitive Domain Measured: Working Memory

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Battery Details

Length:Approx. 12-15 minutes
Administration:Standardized
Data Processing and Scoring:Automated
Application:Phase I-IV; general cognitive screening battery
Culture and Language Neutral:Yes

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Key References

Lim, Y. Y., Ellis, K. A., Harrington, K., Ames, D., Martins, R. N., Masters, C. L., … Group, T. A. R. (2012). Use of the CogState Brief Battery in the assessment of Alzheimer’s disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. J Clin Exp Neuropsychol, 34(4), 345–358.

Lim, Y. Y., Jaeger, J., Harrington, K., Ashwood, T., Ellis, K. a, Stöffler, A., … Maruff, P. (2013). Three-Month Stability of the CogState Brief Battery in Healthy Older Adults, Mild Cognitive Impairment, and Alzheimer’s Disease: Results from the Australian Imaging, Biomarkers, and Lifestyle-Rate of Change Substudy (AIBL-ROCS). Archives of clinical neuropsychology :doi:10.1093/arclin/act021

Maruff, P., Lim, Y. Y., Darby, D., Ellis, K. A., Pietrzak, R. H., Snyder P. J., Bush, A. I., Szoeke, C., Schembri, A., Ames, D., Masters, C. L., & the AIBL Research Group (2013) Clinical utility of the Cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer’s disease. BMC Pharmacology & Toxicology, 1:30

Fredrickson, J., Maruff, P., Woodward, M., Moore, L., Fredrickson, A., Sach, J., Darby, D. (2010) Evaluation of the Usability of a Brief Computerized Cognitive Screening Test in Older People for Epidemiological Studies. Neuroepidemiology, 34: 65-75.

Louey, A. G., Cromer, J. A., Schembri, A. J., Darby, D. G., Maruff, P., Makdissi, M., & Mccrory, P. (2014). Detecting cognitive impairment after concussion: sensitivity of change from baseline and normative data methods using the CogSport/Axon cognitive test battery. Archives of Clinical Neuropsychology, 29(5), 432-441. doi: 10.1093/arclin/acu020