Cogstate’s computerized battery of rapid, reliable, simple and sensitive tasks measures the cognitive domains affected by MCI and AD, namely processing speed, attention, verbal and visual learning, working memory, visual motor and executive function.
The construct validity of each test for cognitive impairment in MCI and AD as well as the sensitivity of these tests to change in cognition has been demonstrated in the scientific literature. The tests have also been shown to be valid for use in different cultures and language groups with comparative/normative data available for both clinical samples and healthy controls. Study teams wishing to measure all or a subset of these domains can choose the tests that best suit their specific research questions. Each of the tests have been utilized previously in drug trials and maintain excellent reliability across repeated testing and cross-sectional research designs.
The Detection Test uses a simple reaction time paradigm to measure processing speed.
Cognitive Domain Measured: Psychomotor Function
The Identification Test uses a choice reaction time paradigm to measure attention.
Cognitive Domain Measured: Attention
One Card Learning Test
The One Card Learning Test uses a pattern separation paradigm to measure visual memory.
Cognitive Domain Measured: Visual Learning
One Back Test
The One Back Test uses an n-back paradigm to measure working memory.
Cognitive Domain Measured: Working Memory
International Shopping List Test
The International Shopping List Test uses a word list learning paradigm to measure verbal learning.
Cognitive Domain Measured: Verbal Learning
International Shopping List Test - Delayed Recall
The Delayed International Shopping List Test (ISLT) uses a word list paradigm to measure verbal memory.
Cognitive Domain Measured: Memory
Continuous Paired Associate Learning Test
The Continuous Paired Associate Learning Test uses a paired associative learning paradigm to measure visual memory.
Cognitive Domain Measured: Paired Associate Learning
Groton Maze Learning Test
The Groton Maze Learning Test uses a maze learning paradigm to measure executive function.
Cognitive Domain Measured: Executive Function
|Length:||Between 5-30 minutes
(depending on the number of tests included in the battery*)
|Data Processing and Scoring:||Automated|
|Culture and Language Neutral:||Yes|
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Lim, Y. Y., Ellis, K. A., Harrington, K., Ames, D., Martins, R. N., Masters, C. L., … Group, T. A. R. (2012). Use of the CogState Brief Battery in the assessment of Alzheimer’s disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology, 34(4), 345–358. doi:10.1080/13803395.2011.643227
Lim, Y. Y., Ellis, K. A., Pietrzak, R. H., Ames, D., Darby, D., Harrington, K., … the AIBL Research Group, F. (2012). Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology, 79(16), 1645–1652. doi:10.1212/WNL.0b013e31826e9ae6
Lim, Y. Y., Ellis, K. A., Ames, D., Darby, D., Harrington, K., Martins, R. N., … Group, A. R. (2012). Aβ amyloid, cognition, and APOE genotype in healthy older adults. Alzheimers Dementia. doi:10.1016/j.jalz.2012.07.004
Lim, Y. Y., Jaeger, J., Harrington, K., Ashwood, T., Ellis, K. A., Stoffler, A., … Maruff, P. (2013). Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer’s disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology, 28(4), 320-330. doi: 10.1093/arclin/act021
Maruff, P., Lim, Y. Y., Darby, D., Ellis, K. A., Pietrzak, R. H., Snyder P. J., Bush, A. I., Szoeke, C., Schembri, A., Ames, D., Masters, C. L., & the AIBL Research Group (2013). Clinical utility of the Cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer’s disease. BMC Pharmacology & Toxicology, 1:30