Cogstate Alzheimer’s Battery

Assess cognitive function in adults with mild cognitive impairment (MCI) and clinically-diagnosed Alzheimer’s disease (AD).

Cogstate’s computerized battery of rapid, reliable, simple and sensitive tasks measures the cognitive domains affected by MCI and AD, namely processing speed, attention, verbal and visual learning, working memory, visual motor and executive function.

The construct validity of each test for cognitive impairment in MCI and AD as well as the sensitivity of these tests to change in cognition has been demonstrated in the scientific literature. The tests have also been shown to be valid for use in different cultures and language groups with comparative/normative data available for both clinical samples and healthy controls. Study teams wishing to measure all or a subset of these domains can choose the tests that best suit their specific research questions. Each of the tests have been utilized previously in drug trials and maintain excellent reliability across repeated testing and cross-sectional research designs.

Cogstate Tests

Detection Test

The Detection Test uses a simple reaction time paradigm to measure processing speed.

Cognitive Domain Measured: Psychomotor Function

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Identification Test

The Identification Test uses a choice reaction time paradigm to measure attention.

Cognitive Domain Measured: Attention

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One Card Learning Test

The One Card Learning Test uses a pattern separation paradigm to measure visual memory.

Cognitive Domain Measured: Visual Learning

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One Back Test

The One Back Test uses an n-back paradigm to measure working memory.

Cognitive Domain Measured: Working Memory

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International Shopping List Test

The International Shopping List Test uses a word list learning paradigm to measure verbal learning.

Cognitive Domain Measured: Verbal Learning

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International Shopping List Test - Delayed Recall

The Delayed International Shopping List Test (ISLT) uses a word list paradigm to measure verbal memory.

Cognitive Domain Measured: Memory

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Continuous Paired Associate Learning Test

The Continuous Paired Associate Learning Test uses a paired associative learning paradigm to measure visual memory.

Cognitive Domain Measured: Paired Associate Learning

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Groton Maze Learning Test

The Groton Maze Learning Test uses a maze learning paradigm to measure executive function.

Cognitive Domain Measured: Executive Function

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Battery Details

Length:Between 5-30 minutes
(depending on the number of tests included in the battery*)
Administration:Standardized
Data Processing and Scoring:Automated
Application:Phase I-IV
Culture and Language Neutral:Yes

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Key References

Darby, D. G., Pietrzak, R. H., Fredrickson, J., Woodward, M., Moore, L., Fredrickson, A., … Maruff, P. (2012). Intraindividual cognitive decline using a brief computerized cognitive screening test. Alzheimer’s and Dementia, 8(2), 95–104. doi:10.1016/j.jalz.2010.12.009

De Jager, C. a, Schrijnemaekers, A.-C. M. C., Honey, T. E. M., & Budge, M. M. (2009). Detection of MCI in the clinic: evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE. Age and ageing, 38(4), 455–60. doi:10.1093/ageing/afp068

Hammers, D., Spurgeon, E., Ryan, K., Persad, C., Barbas, N., Heidebrink, J., … Giordani, B. (2012). Validity of a brief computerized cognitive screening test in dementia. J Geriatric Psychiatry Neurology, 25(2), 89–99. doi:10.1177/0891988712447894.

Hammers, D., Spurgeon, E., Ryan, K., Persad, C., Heidebrink, J., Barbas, N., Albin, R., Frey, K., Darby , D., and Giordani, B. (2011) Reliability of Repeated Cognitive Assessment of Dementia Using a Brief Computerized Battery. American Journal of Alzheimer’s Disease and Other Dementia’s: 26 (4) 326-333.

Lim, Y. Y., Ellis, K. A., Harrington, K., Ames, D., Martins, R. N., Masters, C. L., … Group, T. A. R. (2012). Use of the CogState Brief Battery in the assessment of Alzheimer’s disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology, 34(4), 345–358. doi:10.1080/13803395.2011.643227

Lim, Y. Y., Ellis, K. A., Pietrzak, R. H., Ames, D., Darby, D., Harrington, K., … the AIBL Research Group, F. (2012). Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology, 79(16), 1645–1652. doi:10.1212/WNL.0b013e31826e9ae6

Lim, Y. Y., Ellis, K. A., Ames, D., Darby, D., Harrington, K., Martins, R. N., … Group, A. R. (2012). Aβ amyloid, cognition, and APOE genotype in healthy older adults. Alzheimers Dementia. doi:10.1016/j.jalz.2012.07.004

Lim, Y. Y., Jaeger, J., Harrington, K., Ashwood, T., Ellis, K. A., Stoffler, A., … Maruff, P. (2013). Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer’s disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology, 28(4), 320-330. doi: 10.1093/arclin/act021

Maruff, P.,  Lim, Y. Y., Darby, D., Ellis, K. A., Pietrzak, R. H., Snyder P. J., Bush, A. I., Szoeke, C., Schembri, A., Ames, D., Masters, C. L., & the AIBL Research Group (2013). Clinical utility of the Cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer’s disease. BMC Pharmacology & Toxicology, 1:30